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Saturday, April 7, 2012

How to Adapt to Change in Your Business: Change Management

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www.lifecycle-performance-pros.com Business Performance Expert and Performance Management Consultant Victor Holman illustrates how to manage change within your organization in this rapidly changing economy. Organizational Change, Performance management, metrics, slas, organizational alignment, methodology, business objectives, planning, strategy, Swot analysis, employee performance, key processes, standardization, risks, KPIs, data quality, quality management, reporting, project, decision making, customer satisfaction, business intelligence, scorecard, dashboard, best practices http
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Friday, April 6, 2012

Sponsors of House FCC Reform Bill Pull in Big Money From ...

April 5, 2012-Last week a bill to restructure the Federal Communications Commission?s rulemaking process passed the House of Representatives, 247-174. The measure was supported by AT&T, the National Association of Broadcasters, the National Cable & Telecommunications Association, and Verizon Communications, all of which are major contributors to the bill?s 10 sponsors.

H.R. 3309, sponsored by Greg Walden (R-Ore.) and nine other co-sponsors, would establish additional requirements for the FCC before the agency could issue new regulations. These would include identifying a specific market failure or harm that warrants new rules, holding a longer public comment period, and providing a cost-benefit analysis of all regulations applied. It would also limit the ability of the agency to include any terms on corporate mergers. Lawmakers supporting the bill say it would ensure the FCC?s enactment of more appropriate rules, shorten its reaction time, and allow for more public input to the agency, while opponents say it is simply an attempt to hamstring the FCC and make it more difficult to fulfill its public interest function.

The FCC has authority to regulate many communications sectors, including telephone, cable television, broadband internet, broadcast radio and television, satellite television, and radio spectrum allocation. Eight of the bill?s 10 sponsors have at least one, if not several, FCC-regulated companies among their top 10 contributing organizations. Comcast made the top 10 list of five sponsors, while the National Cable & Telecommunications Association made four top 10 lists.

Senate Democrats have said that they will not pass the bill, and President Obama has indicated that he may veto the bill if it reaches his desk. Despite this, several industry groups have already praised the passage of the bill, with National Cable & Telecommunications Association president Michael Powell commending Walden for his attempt to reform the FCC.

Police : Gunman targeted different administrator

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Thursday, April 5, 2012

Malaysia police arrest 137 in gambling bust

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'American Idol' Loves The '80s: What Should They Sing?

MTV News' Gil Kaufman and James Montgomery face off over song selections for the 'Idol' top eight.
By Gil Kaufman and James Montgomery

"American Idol" top eight
Photo: FOX

Last week, we tried to give the "American Idol" top nine some helpful advice with a selection of songs they should sing during Idols week. Of course, they mostly ignored us — except for our girl J.Sanch, who totally did Beyoncé and advanced — but we remain undeterred, which is why we're back this week with even more picks.

This time out, "Idol" is taking us back to the 1980s, which is great news for both Randy Jackson and Steven Tyler, but totally makes us wish Heejun Han was still around; we'd pay good money to see him do "Weird Al" Yankovic's "Living With a Hernia." But that doesn't mean there aren't plenty of great opportunities for the remaining eight. After all, this was the decade that gave us both the Rubik's Cube and Flock of Seagulls, two things that remind us, respectively, of Hollie Cavanagh (plastic, square) and Colton Dixon (terrible hair). Also, 1988 was the year Seacrest stopped growing. Everyone should feel right at home this week — even if they weren't alive during the actual 1980s.

So without further ado, here are our picks. We may rarely agree, but we know music and we know reality singing shows, and these are the songs the "Idol" finalists must pick in order to make it to the next round:

Jessica Sanchez
J.Sanch is in the driver's seat, which means she can pretty much do what she wants. Ballads are her go-to, and while she could really show her full range with a good uptempo song, Cyndi Lauper's classic weeper "Time After Time" is a bull's-eye for her. — Gil Kaufman

She already did Whitney (to max effect), which is a shame because "Greatest Love of All" or "I Wanna Dance With Somebody" would've been prime picks for her this week. So where does she turn instead? How about Bette Midler's "Wind Beneath My Wings"? It's the kind of inspirational, big-boned ballad Sanchez has killed in previous weeks, and the resident "Idol" diva-in-training could certainly learn a few things from the Divine Miss M. — James Montgomery

Hollie Cavanagh
We'll dispense with the pixie allusions and get to the meat: Hollie needs to smash it this week or else it could mean a trip back to the suburban mini-mansion. Jimmy said last week that she's got the chops but isn't connecting with the songs, so she needs a tune that will let her do both. Cue "I Want to Know What Love Is" by Foreigner. The emotion is built in, and it's impossible to sing it without sounding forlorn. — Kaufman

She's on thin ice with viewers, who are growing tired of her by-the-numbers balladry, and she needs a powerhouse performance this week to stay in the competition. So what better time for a complete makeover? (Hey, it worked for Elise Testone ... ) I'm thinking she should do something from Madonna's early '80s catalog, like "Borderline" or "Material Girl." Shoot, if she really wants to swing for the fences, why not "Like a Virgin"? Folks would certainly be talking after that one ... — Montgomery

Joshua Ledet
He's back! After a shaky stretch, the gospel-dipped power vocalist stormed back last week and almost nailed it (if he hadn't cried, St. Jimmy said Ledet would have been on top of the leaderboard). The '80s are lousy with options for Mantasia, from Chaka Khan and Rufus' "Ain't Nobody" to Anita Baker's "Sweet Love." Ledet should be in heaven. — Kaufman

Down one week, up the next, Josh scored with Mariah last week, and he could do the same this week by taking on anything from '80s-era Lionel Richie. "Hello," "Truly," "All Night Long" — take your pick. He'd sing the crap out of any of 'em. — Montgomery

DeAndre Brackensick
D.Brack does one thing well: bust out that feathery falsetto. (OK, two things: He's also a helluva hair flipper.) I'm the only person on the planet who would say this, but those two talents can only mean one thing: Terence Trent D'Arby. As TTD's #1 (and maybe only remaining) fan, I can honestly say that 'Dre can smash it with either "If You Let Me Stay" or "Wishing Well." Both have ample falsetto-tunities and, well, they're just awesome. — Kaufman

After proving last week that he's apparently impervious to elimination, DeAndre is clearly playing with house money at this point, so why not just go for it and sing Musical Youth's "Pass the Dutchie"? Just remember to pass it from the left-hand side, D! — Montgomery

Skylar Laine
I give up on trying to convince Laine that she should step out of the country corral and show off some Carrie Underwood-style crossover potential. We get it: Your boots only scoot one way. The '80s were chock-full of big, cheesy country ballads, but Restless Heart's "I'll Still Be Loving You" is the biggest and cheesiest, making it as crucial a staple at big hair weddings as a gingham dress, camouflage overalls and a Twinkie-topped wedding cake. — Kaufman

Is this the week she steps outside the country bubble? Hell no. And since she used to get compared to Reba McEntire all the time, what better week to tackle one of her tunes? I could see her doing "How Blue" or "Someone Should Leave." Or maybe she'll shock us all and do some Crüe? Oh, who am I kidding? — Montgomery

Colton Dixon
By now you've probably noticed that my esteemed colleague James is a serious Dixon Denier. He just doesn't get it, and while I don't love C.Dix, I get why the girls do. He's proven to have Velveeta-level song-choice skills so far, but maybe the worship side of him can come around to something from U2 that would show his arena-rocking potential, such as the vaguely spiritual "I Still Haven't Found What I'm Looking For" or "With or Without You." — Kaufman

So many options for him this week. I could see him building on last week's worship-tastic Lifehouse performance by taking on some Stryper or embracing his inner cheese-monger by doing something like Bon Jovi's "Wanted Dead or Alive." In a pinch, I'll take the latter, since I suspect he fancies himself a bit of a cowboy anyway. Though he'd probably need to change his haircut if he wants to get served in any saloon. — Montgomery

Phillip Phillips
I'm not ashamed to admit I just don't get this dude. Phil-Squared just seems like no fun to me, and his "talent" is basically making every song sound like a jittery attempt to clear his throat. Like Dixon, he's got the musical taste of a Southern frat boy who was banned from the "devil's music" as a kid. What the hell, let's see how badly he can mangle the Police's "Every Breath You Take" or Phil Collins' "Against All Odds (Take a Look at Me Now)." — Kaufman

He's gonna growl. He's gonna shout. Shoot, he'll probably grout. And is there a better song to do it to than Scorpions' "Rock You Like a Hurricane"? Probably not. In all seriousness, I could actually see him slowing this one down and putting his own unique spin on it, which could make for the first time I actually enjoyed a Phillip Phillips performance. — Montgomery

Elise Testone
Elise appears to have fully embraced her inner-rock queen, so she should stick to that. Bon Jovi's "Livin' on a Prayer" or Guns N' Roses' "Sweet Child O' Mine" are the only way to go. But she'll probably stick to the script and do Bonnie Tyler's "Total Eclipse of the Heart." — Kaufman

She's found her footing over the past two weeks and now appears capable of singing just about anything. I could see her going Sunset Strip skuzzy this week, though I'm hoping she does Journey's "Don't Stop Believin'," which has both the smoke and the soul. As an added bonus, "Idol" producers could just cut to black right before she hits the triumphant chorus, leaving us all to wonder whether she's just been whacked. — Montgomery

Get your "Idol" fix on MTV News' "American Idol" page, where you'll find all the latest news, interviews and opinions.

Related Photos

'American Idol' Season 11 Top 13 Contestants

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DNA sequencing consortium unveils patterns of mutations in autism

ScienceDaily (Apr. 4, 2012) ? It has long been recognized that autism runs in families, suggesting a substantial genetic component to the disease. Yet few genes have so far been identified and the underlying genetic architecture of autism -- that is, how many genes contribute and to what extent they influence a person's chances of developing the disorder -- remains poorly understood.

Now, a consortium led by researchers from the Broad Institute, Massachusetts General Hospital (MGH), and six other organizations has taken a step toward addressing these questions by searching for mutations in the fraction of the human genome that codes for proteins. The researchers sequenced this region, known as the "exome," in 175 autism patients and their unaffected parents, looking for single-letter DNA changes present only in the children. Their results, along with simultaneously published findings from two other research groups, suggest modest roles for hundreds of genes in the development of autism and pinpoint a few specific genes as genuine risk factors. The work is described in a paper that appears online April 4 in the journal Nature.

"Autism, like many heritable disorders, results from the action of many genes -- not simply a single gene as in cystic fibrosis or Huntington's disease," said senior author Mark Daly, chief of the Analytic and Translational Genetics Unit at MGH, a senior associate member of the Broad Institute and co-director of its Program in Medical and Population Genetics, and a member of the Broad Institute's Stanley Center for Psychiatric Research. "These genes hold key insights into the true biological causes of autism -- insights we have been unable to gain through other lines of research."

Autism is a common neurodevelopmental disorder characterized by impaired social, behavioral, and communication abilities. Compared to other complex diseases, which are caused by a complicated mix of genetic, environmental, and other factors, autism is highly heritable -- genetics accounts for roughly 80-90% of the risk of developing autism. Yet the majority of autism cases cannot be attributed to known inherited causes.

Researchers in the ARRA Autism Sequencing Collaborative (AASC) -- formed by researchers from the Broad Institute, MGH, Baylor College of Medicine, Mount Sinai School of Medicine, Vanderbilt University, University of Pennsylvania, Carnegie Mellon University, and University of Pittsburgh -- used massively parallel sequencing to help shed light on the genes that influence autism risk. Concordant findings from separate studies by two other groups, from Yale University and the University of Washington respectively, also appear in Nature.

The AASC team focused its attention on a particular set of mutations, specifically single-letter mutations that are not present in the parents' DNA but instead appeared spontaneously in the children -- so-called de novo point mutations. Although it is not yet clear exactly when these changes arise, such genetic variations tend to be rare but also more severe in their impact on gene function. With such extreme effects, they can serve as important signposts toward genes involved in autism.

"The idea is that these de novo mutations can help identify candidate genes much more precisely because a newly arisen point mutation is considered really strong evidence that the mutation -- and the gene it resides in -- is involved in autism," said first author Benjamin Neale, a research affiliate at the Broad Institute and an assistant in genetics at MGH.

The researchers found that less than half of the autism cases studied carried a potentially protein-altering de novo point mutation. While this was only slightly higher than the number expected based on the rate of mutation in the general population, these events are sufficiently rare that they could be used to uncover specific risk genes.

"These data suggest that there is a role for de novo point mutations in the coding region of the genome for autism, but they do not constitute a sufficient cause," said Neale. "That is to say, most de novo variants do not fully explain the disorder in an individual."

To learn more about these mutations and the genes in which they reside, the scientists looked for any meaningful connections among them. Such connections, among different proteins for example, might reveal important biological networks or pathways that underlie autism. By mining these data, Daly, Neale, and their colleagues found that the mutated genes are more connected to each other and to previously identified autism genes than expected. Specifically, the results suggest that some of the proteins encoded by these genes physically interact with each other.

As described in their paper, Daly and his colleagues pooled their data with those published in the other two Nature papers, revealing 18 candidate genes with multiple functional de novo point mutations. Considering the severity of the mutations, the collective results pointed to three genes as strong autism candidates: KATNAL2, a gene whose function is unknown; SCN2A, which encodes a brain protein that forms a channel for sodium ions; and CHD8, a gene that regulates gene transcription and modifies chromatin (the network of proteins that surrounds DNA).

The AASC team used additional exome sequencing of nearly 1000 autism cases and as many controls to validate these findings and uncovered strong evidence supporting two of the three candidate genes, KATNAL2 and CHD8. Together, the genes help explain less than one percent of the genetic risk of autism.

"These results clearly demonstrate the potential of DNA sequencing to articulate specific risk factors for autism," said Daly. "We have only scratched the surface, but with continued collaborative efforts, these gene discoveries will point us to the underlying biological roots of autism."

The research described in the Nature paper was supported by ARRA funding from the National Human Genome Research Institute and the National Institute of Mental Health.

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The above story is reprinted from materials provided by Broad Institute of MIT and Harvard.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Benjamin M. Neale, Yan Kou, Li Liu, Avi Ma?ayan, Kaitlin E. Samocha, Aniko Sabo, Chiao-Feng Lin, Christine Stevens, Li-San Wang, Vladimir Makarov, Paz Polak, Seungtai Yoon, Jared Maguire, Emily L. Crawford, Nicholas G. Campbell, Evan T. Geller, Otto Valladares, Chad Schafer, Han Liu, Tuo Zhao, Guiqing Cai, Jayon Lihm, Ruth Dannenfelser, Omar Jabado, Zuleyma Peralta, Uma Nagaswamy, Donna Muzny, Jeffrey G. Reid, Irene Newsham, Yuanqing Wu, Lora Lewis, Yi Han, Benjamin F. Voight, Elaine Lim, Elizabeth Rossin, Andrew Kirby, Jason Flannick, Menachem Fromer, Khalid Shakir, Tim Fennell, Kiran Garimella, Eric Banks, Ryan Poplin, Stacey Gabriel, Mark DePristo, Jack R. Wimbish, Braden E. Boone, Shawn E. Levy, Catalina Betancur, Shamil Sunyaev, Eric Boerwinkle, Joseph D. Buxbaum, Edwin H. Cook, Bernie Devlin, Richard A. Gibbs, Kathryn Roeder, Gerard D. Schellenberg, James S. Sutcliffe, Mark J. Daly. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature, 2012; DOI: 10.1038/nature11011

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Khloe Kardashian Kovers Kosmo Sex Issue, Talks Naked Cooking

Khloe Kardashian covers the Sex Issue of Cosmopolitan this month, which is funny for two reasons:

Isn't every issue of Cosmopolitan the Sex Issue?
Is Khloe Kardashian the first person you think of - heck, the first person you think of in her own family - when you think of sex?

In an interview with the publication, the reality star dishes on everything from weigh gain to naked cooking. Read on a few excerpts:

On Kris Jenner, Momager: “Listen, my mom believes in us more than we believe in ourselves. But she is also our manager and trying to protect our brand. She’ll say, ‘Oh, you’re a little too fat right now.’ If she were just my manager, I’d have fired her right then. You can’t talk to me like that.”

What kind gestures does she perform for husband Lamar Odom? "I cook for him naked."

Will she ever be a mother? "Lamar and I definitely want kids, and when it happens for us, it will happen."

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Saturday, April 7, 2012

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